This must be one of the strangest games I've ever played. I never really got it while I was young, because I've never seen those movies that the game refers to.
Now at a later age, I can accept why this game was created and smile at some of the references to Them! and other classic 50's movies. Still, it is not a good game, as giant Ants keep interrupting gameplay at worst possible times.
I remember the hospital scenes to be the best. You need to escape from the hospital and angry doctors are chasing you around. That was the primary reason for playing this game.